Macromolecular crowding in protein misfolding and aggregation studied by single-molecule force spectroscopy

单分子力谱研究蛋白质错误折叠和聚集中的大分子拥挤

• 批准号: 242784
• 负责人: Hoffmann Armin
• 金额: $ 6.56万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-10-01 至 2013-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=242784&lang=en
• 关键词: Macromolecular Crowding; Parkinsin'S Disease; Prion Disease; Protein (Mis-)Folding Diseases; Protein Aggregation; Single-Molecule Force Spectroscopy

In order to fulfill their essential roles in the cell, proteins have to fold into specific three-dimensional structures. Understanding how this takes place is a key scientific challenge, especially because proteins can also fold into the wrong structures

为了在细胞中发挥重要作用，蛋白质必须折叠成特定的三维结构。了解这是如何发生的是一个关键的科学挑战，特别是因为蛋白质也可以折叠成错误的结构