Infrastructure for poultry viral immunology studies

开发新的疫苗和疾病治疗方法已被加拿大家禽业确定为优先研究领域。由于经济和公共卫生意义、控制措施的成本以及现有控制措施的问题，呼吸道病毒感染引起的疾病对家禽业的影响是巨大的。严重致病病毒株的出现已成为一个常见问题，因此，疾病暴发现在经常发生在接种疫苗的鸡群中。因此，确定针对鸡呼吸道病毒的可持续控制措施至关重要。拟议的基础设施，其中包括高遏制家禽隔离单位和生物安全柜，将支持一项研究计划，以调查先天免疫引起的呼吸道病毒感染。该研究计划预计将提供对呼吸道粘膜诱导的先天免疫机制的基本理解，以对抗病毒感染。由于研究的转化性质，我们计划的结果将作为开发新的鸡呼吸道病毒感染控制措施的基础。鉴于先天免疫应答的非特异性，可以设想将相同的原理应用于在鸡和火鸡工业中都很重要的其他家禽微生物感染的潜力。这将促进加拿大和其他地方机构之间的合作。能够与家禽业合作的高素质研究人员的严重短缺已经造成了加拿大家禽业和支持联邦机构的限制。为了解决这个问题，家禽业已经建立了一个倡议，以支持家禽科学的研究生学习。加拿大公民和移民部已经开始提供临时签证，以吸引来自其他北美国家的家禽科学家在加拿大工作。在这种背景下，该研究计划与所要求的基础设施的援助将提供一个长期的利益，使高素质的人员，以解决长期面临的健康问题，加拿大家禽业。

Development of new vaccines and treatments for diseases has been identified as a priority research area by the Canadian poultry industry. Due to economic and public health significance, the cost of control measures and also due to the problems of existing control measures, the impact of diseases caused by respiratory viral infections on the poultry industry is enormous. The emergence of severe disease-causing strains of the viruses has become a common problem and, as a result, disease outbreaks now frequently occur in vaccinated flocks. Therefore, it is vital to identify sustainable control measures against respiratory viruses in chickens. The proposed infrastructure, which includes high containment poultry isolation units and biosafety cabinets, will support a research program to investigate innate immunity elicited against respiratory viral infections. The research program is expected to provide a fundamental understanding of innate immune mechanisms induced in the respiratory mucosa against viral infections. Due to the translational nature of the research, the findings of our program will serve as a basis for the development of novel control measures against respiratory viral infections in chickens. Given the non-specific nature of innate immune responses, one may envision the potential of applying the same principle to other poultry microbial infections that are important in both the chicken and turkey industries. This will promote collaborations among institutions in Canada and elsewhere. Acute shortages of highly qualified research personnel capable of collaborating with the poultry industry has created a constraint identified by both the Canadian poultry industry as well as supporting federal agencies. To address this problem, the poultry industry has established an initiative to support graduate studies in poultry science. Citizenship and Immigration Canada has started a process of providing temporary visas to attract poultry scientists from other North American countries to work in Canada. Given this background, the research program with the aid of requested infrastructure would provide a long-term benefit by making highly qualified personnel available to address long-term health problems confronting the Canadian poultry industry.