Solution- and Solid-State 500 MHz Nuclear Magnetic Resonance Facility Upgrade

申请人请求支持升级莱斯布里奇大学的500 MHz核磁共振（NMR）光谱仪。NMR光谱是用于分析纯化合物、混合物和生物样品的分子结构和动力学的主要工具。在过去的十年里，该仪器一直是核磁共振设施的支柱。它为莱斯布里奇大学的24名主要研究人员提供服务，或与莱斯布里奇大学的研究人员合作，研究领域包括：材料科学，无机化学，有机化学，催化，生物物理学，环境科学，能源研究和NMR成像。核磁共振设施是众多本科生和研究生以及博士后研究员培训的核心。我们的设备特别适合含氟材料的研究。氟存在于所有药物的40%中，并广泛用于与替代能源，环境技术和电子应用相关的材料中。然而，对这种元素的研究对NMR仪器和实验提出了特殊的要求。翻新的500 MHz NMR光谱仪是莱斯布里奇大学应用氟化学卓越中心的重要组成部分，这在世界上是独一无二的。拟议的一系列修改将以最具成本效益的方式产生最大的影响，从而使科学卓越的延续和下一代科学家的培训成为可能。这项投资仅占全部更换估计成本的12.5%，并将延长仪器的使用寿命至少10年。这一升级将使莱斯布里奇大学继续定义现代氟化学的前沿。

The applicants request support for upgrading the University of Lethbridge's 500 MHz nuclear magnetic resonance (NMR) spectrometer. NMR spectroscopy is the main tool used to analyze molecular structures and dynamics of pure compounds, mixtures and biological samples. This instrument has been the mainstay of the NMR facility over the last ten years. It serves 24 principle investigators at or in collaboration with those at the University of Lethbridge in research areas including: materials science, inorganic chemistry, organic chemistry, catalysis, biophysics, environmental science, energy research, and NMR imaging. The NMR facility is central to the training of numerous undergraduate and graduate students and postdoctoral fellows. Our facility is especially optimized for the study of fluorine-containing materials. Fluorine is present in 40% of all pharmaceuticals, and is used extensively in materials related to alternative energy, environmental technology, and electronics applications. The study of this element, however, places special demands on NMR instrumentation and experiments. A refurbished 500 MHz NMR spectrometer is the essential component of the centre of excellence at the University of Lethbridge in applied fluorine chemistry, which is unique in the world. The proposed series of modifications will have the maximum impact in the most cost effective manner, thereby enabling continuation of scientific excellence and training of the next generation of scientists. This investment represents a mere 12.5% of the estimated cost of full replacement and will extend the operational lifetime of the instrument by at least 10 years. This upgrade will allow the University of Lethbridge to continue to define the cutting edge of modern fluorine chemistry.