Rodent ultrasonic vocalizations, reward and striatal function

啮齿动物超声波发声、奖励和纹状体功能

• 批准号: 155055-2008
• 负责人: Clarke, Paul
• 金额: $ 1.96万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=497207
• 关键词: Rodent; ultrasonic; vocalizations; reward; striatal

The main aim of this proposal is to increase our understanding of brain activity related to rewarding events and their effects on behaviour. We know that different parts of the brain are specialized for different functions, and the main areas of the brain that are involved in the processing of reward have been identified. Certain neurotransmitters (signalling molecules) have been shown to be important players in this reward process. The best known of these is dopamine. In popular culture, this neurotransmitter is often equated with pleasure. However, evidence suggests that dopamine release has little to do with reward enjoyment; for example, it is often released before a reward is received. Hence, dopamine release may have less to do with pleasure, and more to do with reward anticipation or with motivation to obtain a reward.

这一提议的主要目的是增加我们对与奖励事件及其对行为的影响相关的大脑活动的理解。我们知道，大脑的不同部分负责不同的功能，并且已经确定了大脑中参与奖励处理的主要区域。某些神经递质（信号分子）已被证明在这个奖励过程中起着重要作用。其中最著名的是多巴胺。在流行文化中，这种神经递质通常等同于快乐。然而，有证据表明，多巴胺的释放与奖励享受几乎没有关系；例如，它通常在收到奖励之前被释放。因此，多巴胺的释放可能与愉悦感关系不大，而更多地与奖励预期或获得奖励的动机有关。