Order restricted statistical inference and its applications
阶数限制统计推断及其应用
基本信息
- 批准号:261301-2008
- 负责人:
- 金额:$ 1.02万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2012
- 资助国家:加拿大
- 起止时间:2012-01-01 至 2013-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
When you go to the pharmacy and fill a prescription up, have you ever wondered if the dose of the drug is right for you? Can the dose be too low so that the drug will not work? Can the dose be too high that it may cause some side effects? Have you ever thought about how Health Canada makes a decision to approve or to reject a new drug? Some of these questions can be answered by dose-response and toxicity studies in this research. For example, dose-response studies are useful in Phase II and Phase III clinical trials to evaluate efficacy and toxicity of a drug in order to determine its effective and safe ranges. A zero dose is generally included as a control against which higher doses are compared. This naturally leads to multiple comparisons. The ordered nature of doses suggests the use of stepwise procedures and the utilization of such ordering information to increase the efficiency of statistical procedures. Statistical inference under order restrictions has been a very active area of research motivated by problems in areas such as medicine, toxicology, engineering and economics. In this research proposal we will develop several simple and effective methods by utilizing different types of prior ordering information which arise naturally in dose-response and toxicity studies, and quantal bioassay.
当你去药房配药时,你有没有想过药物的剂量是否适合你?剂量会不会太低而导致药物不起作用?剂量是否过高,可能会导致一些副作用?你有没有想过 加拿大卫生部如何决定批准或拒绝一种新药?其中一些问题可以通过本研究中的剂量反应和毒性研究来回答。 例如,剂量反应研究在II期和III期临床试验中用于评估药物的功效和毒性,以确定其有效和安全范围。通常包括零剂量作为对照,与较高剂量进行比较。这自然会导致多重比较。剂量的有序性表明应使用逐步程序,并利用这种有序信息来提高统计程序的效率。序限制下的统计推断一直是一个非常活跃的研究领域 受医学、毒理学、工程学和经济学等领域问题的推动。 在这项研究中,我们将开发几个简单而有效的方法,利用不同类型的事先排序信息,自然产生的剂量反应和毒性研究,和量子生物测定。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Peng, Jianan其他文献
Multiple confidence intervals for selected parameters adjusted for the false coverage rate in monotone dose-response microarray experiments
- DOI:
10.1002/bimj.201500254 - 发表时间:
2017-07-01 - 期刊:
- 影响因子:1.7
- 作者:
Peng, Jianan;Liu, Wei;Shkedy, Ziv - 通讯作者:
Shkedy, Ziv
Peng, Jianan的其他文献
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{{ truncateString('Peng, Jianan', 18)}}的其他基金
New methods for multiple comparison procedures
多重比较程序的新方法
- 批准号:
RGPIN-2018-05119 - 财政年份:2022
- 资助金额:
$ 1.02万 - 项目类别:
Discovery Grants Program - Individual
New methods for multiple comparison procedures
多重比较程序的新方法
- 批准号:
RGPIN-2018-05119 - 财政年份:2021
- 资助金额:
$ 1.02万 - 项目类别:
Discovery Grants Program - Individual
New methods for multiple comparison procedures
多重比较程序的新方法
- 批准号:
RGPIN-2018-05119 - 财政年份:2020
- 资助金额:
$ 1.02万 - 项目类别:
Discovery Grants Program - Individual
New methods for multiple comparison procedures
多重比较程序的新方法
- 批准号:
RGPIN-2018-05119 - 财政年份:2019
- 资助金额:
$ 1.02万 - 项目类别:
Discovery Grants Program - Individual
New methods for multiple comparison procedures
多重比较程序的新方法
- 批准号:
RGPIN-2018-05119 - 财政年份:2018
- 资助金额:
$ 1.02万 - 项目类别:
Discovery Grants Program - Individual
Topics in multiple comparison procedures and variable selection
多重比较过程和变量选择的主题
- 批准号:
261301-2013 - 财政年份:2017
- 资助金额:
$ 1.02万 - 项目类别:
Discovery Grants Program - Individual
Topics in multiple comparison procedures and variable selection
多重比较过程和变量选择的主题
- 批准号:
261301-2013 - 财政年份:2016
- 资助金额:
$ 1.02万 - 项目类别:
Discovery Grants Program - Individual
Topics in multiple comparison procedures and variable selection
多重比较过程和变量选择的主题
- 批准号:
261301-2013 - 财政年份:2015
- 资助金额:
$ 1.02万 - 项目类别:
Discovery Grants Program - Individual
Topics in multiple comparison procedures and variable selection
多重比较过程和变量选择的主题
- 批准号:
261301-2013 - 财政年份:2014
- 资助金额:
$ 1.02万 - 项目类别:
Discovery Grants Program - Individual
Topics in multiple comparison procedures and variable selection
多重比较过程和变量选择的主题
- 批准号:
261301-2013 - 财政年份:2013
- 资助金额:
$ 1.02万 - 项目类别:
Discovery Grants Program - Individual
相似国自然基金
压缩感知理论中满足可重构条件的测量矩阵研究
- 批准号:61002024
- 批准年份:2010
- 资助金额:20.0 万元
- 项目类别:青年科学基金项目
相似海外基金
Order restricted statistical inference and its applications
阶数限制统计推断及其应用
- 批准号:
261301-2008 - 财政年份:2011
- 资助金额:
$ 1.02万 - 项目类别:
Discovery Grants Program - Individual
Order restricted statistical inference and its applications
阶数限制统计推断及其应用
- 批准号:
261301-2008 - 财政年份:2010
- 资助金额:
$ 1.02万 - 项目类别:
Discovery Grants Program - Individual
Order restricted statistical inference and its applications
阶数限制统计推断及其应用
- 批准号:
261301-2008 - 财政年份:2009
- 资助金额:
$ 1.02万 - 项目类别:
Discovery Grants Program - Individual
Order restricted statistical inference and its applications
阶数限制统计推断及其应用
- 批准号:
261301-2008 - 财政年份:2008
- 资助金额:
$ 1.02万 - 项目类别:
Discovery Grants Program - Individual
Order restricted statistical inference and stochastic ordering
顺序限制统计推断和随机排序
- 批准号:
4541-1997 - 财政年份:2000
- 资助金额:
$ 1.02万 - 项目类别:
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Order restricted statistical inference and stochastic ordering
顺序限制统计推断和随机排序
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4541-1997 - 财政年份:1999
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$ 1.02万 - 项目类别:
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4541-1997 - 财政年份:1998
- 资助金额:
$ 1.02万 - 项目类别:
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Order restricted statistical inference and stochastic ordering
顺序限制统计推断和随机排序
- 批准号:
4541-1997 - 财政年份:1997
- 资助金额:
$ 1.02万 - 项目类别:
Discovery Grants Program - Individual
Reliability, Statistical Applications of Order Restricted Methods
阶次限制方法的可靠性、统计应用
- 批准号:
9704400 - 财政年份:1997
- 资助金额:
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Continuing Grant
Theory and application of order restricted statistical inference
阶次限制统计推断的理论与应用
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4541-1993 - 财政年份:1996
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