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The role of E2F family proteins on programmed cell death during drosophila development

E2F家族蛋白在果蝇发育过程中程序性细胞死亡中的作用

基本信息

批准号：
355760-2008
负责人：
Moon, NamSung
金额：
$ 2.19万
依托单位：
McGill University
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2012
资助国家：
加拿大
起止时间：
2012-01-01 至 2013-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=498173
关键词：
role E2F family proteins programmed

项目摘要

The shape and size of multi-cellular organisms are determined by the coordination of the cell division and cell death pathways. Cell division produces sufficient masses of cells while cell death prevents over-production. These processes are regulated at the genetic level by several key genes. Studying how theses genes function helps us to understand how an organism grows during development and has potential importance in understanding the manifestation of certain diseases. A number of key genes involved in coordinating cell division belong to a family of evolutionarily conserved genes called E2Fs. E2Fs have the ability to promote both cell division and cell death. Indeed, E2Fs are shown to play important roles in controlling cell number in many different organisms including the fruit fly, Drosophila Melanogaster. Here, I propose to use Drosophila to investigate the role of E2Fs in cell death during development. While the function of E2Fs in cell division has been extensively studied, their role in cell death has been difficult to study due to the technical limitation. Recent advances in molecular and genetic techniques have made Drosophila an ideal system to study the effects of E2Fs on cell death during development. Both molecular and genetic analysis will be used to study how E2Fs coordinate cell division and cell death during Drosophila development. Furthermore, the most recent genetic techniques will be applied to develop tools that will facilitate this study.

多细胞生物的形状和大小是由细胞分裂和细胞死亡途径的协调决定的。细胞分裂产生足够的细胞质量，而细胞死亡防止过度生产。这些过程在遗传水平上由几个关键基因调控。研究这些基因的功能有助于我们了解生物体在发育过程中如何生长，并对理解某些疾病的表现具有潜在的重要性。参与协调细胞分裂的许多关键基因属于称为E2Fs的进化保守基因家族。E2F具有促进细胞分裂和细胞死亡的能力。事实上，E2Fs在许多不同的生物体中，包括果蝇（Drosophila Melanogaster），在控制细胞数量方面发挥着重要作用。在这里，我建议使用果蝇研究E2Fs在细胞死亡过程中的作用。虽然E2 F在细胞分裂中的功能已被广泛研究，但由于技术限制，它们在细胞死亡中的作用一直难以研究。近年来，分子和遗传学技术的发展使果蝇成为研究E2Fs对发育过程中细胞死亡影响的理想系统。分子和遗传分析将用于研究E2Fs如何协调果蝇发育过程中的细胞分裂和细胞死亡。此外，将应用最新的遗传技术开发有助于这项研究的工具。