Substrate stiffness controls the phagocytic activity of myofibroblasts

基质硬度控制肌成纤维细胞的吞噬活性

• 批准号: 251791
• 负责人: Shnier Stefani H
• 金额: $ 0.36万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2012-04-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=251791&lang=en
• 关键词: Contraction; Extracellular Matrix; Fibrosis; Myofibroblast; Phagocytosis; Tissue Repair

After injury, our body rapidly repairs the damage, often leaving behind a stiff scar. Scarring is a clinical burden because affected organs are losing vital functions. A scarred heart cannot pump properly, scarred lung tissue impairs proper gas exchange,

受伤后，我们的身体会迅速修复损伤，往往会留下僵硬的疤痕。疤痕形成是一种临床负担，因为受影响的器官正在失去重要功能。伤痕累累的心脏不能正常泵血，伤痕累累的肺组织会损害正常的气体交换，