MMP-2 small interfering RNA protects against contractile dysfunction in isolated cardiomyocytes subjected to ischemia/reperfusion.

MMP-2 小干扰 RNA 可防止缺血/再灌注的离体心肌细胞出现收缩功能障碍。

• 批准号: 253720
• 负责人: Lin Hanbin
• 金额: $ 0.09万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2012-02-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=253720&lang=en
• 关键词: Cardiomyocyte Contractility Measuremnet; Cardiomyocyte Primary Culture; Chemical Ischemia; Ischemia/Reperfusion Injury; Matrix Mettaloproteinase-2(Mmp-2); Mmp-2 Sirna Transfection; Western Blot; Zymography

Background: In the development of cardiac injury and contractile dysfunction caused by ischemia/reperfusion, matrix mettaloproteinase-2(MMP-2) may be one of the important proteins related to the mechanism of contractile dysfunction. We have shown that pho

背景资料：基质金属蛋白酶-2（matrix metalloproteinase-2，MMP-2）可能是心肌缺血再灌注损伤和收缩功能障碍的重要蛋白质之一。我们已经证明，