Assessing neonatal brain fuction wit fMRI

用功能磁共振成像评估新生儿脑功能

• 批准号: 414500-2012
• 负责人: Cusack, Rhodri
• 金额: $ 7.1万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=503902
• 关键词: Assessing; neonatal; brain; fuction; wit

Brain injury before or during birth can lead to cognitive and behavioural deficits that have long-term implications. If care is to be provided when it is most effective, these deficits must be detected early. Neonates, however, have a limited range of neurobehavioural responses and current tests are inadequate. Although a substantial literature now exists on using neuroimaging to measure brain function in adults, this work has not been translated effectively to assessing function and dysfunction in the neonatal brain. A first key challenge is that neonates are different from adults, both behaviourally and physiologically; they cannot be asked to remain still during the imaging process and the chemical structure of their brain differs significantly from that of the adult brain. We will apply new acquisition and analysis methods to solve these problems, thereby establishing reliable neuroimaging protocols for the neonatal brain. A second challenge is to sensitively and reliably assess cognitive function in neonates. We will identify suitable stimulation protocols, drawing on a hierarchical design that has been previously applied by our team to the problem of assessing cognitive function in adult patients who are diagnosed as vegetative. In the first weeks of life, we will use functional neuroimaging to characterize basic sensory processing, recognition and memory, and acquire state-of-the-art neuroanatomical measures. A third challenge is to evaluate how to combine these measures to best predict later developmental outcome. In collaboration with the Children's Hospital and London Health Sciences Centre, we will develop a tool for clinical practice that combines anatomical, functional and neurobehavioural assessments to improve diagnostic accuracy and facilitate early intervention

出生前或出生期间的脑损伤可能会导致认知和行为缺陷，从而产生长期影响。如果要在最有效的时候提供护理，就必须及早发现这些缺陷。然而，新生儿的神经行为反应范围有限，目前的测试还不够充分。尽管现在有大量关于使用神经影像学来测量成人大脑功能的文献，但这项工作尚未有效地转化为评估新生儿大脑的功能和功能障碍。第一个关键挑战是新生儿在行为和生理上都与成人不同。不能要求他们在成像过程中保持静止，而且他们大脑的化学结构与成人大脑显着不同。我们将应用新的采集和分析方法来解决这些问题，从而为新生儿大脑建立可靠的神经成像方案。第二个挑战是敏感且可靠地评估新生儿的认知功能。我们将利用我们团队之前应用于评估被诊断为植物人的成年患者认知功能问题的分层设计，确定合适的刺激方案。在生命的最初几周，我们将使用功能神经影像来表征基本的感觉处理、识别和记忆，并获得最先进的神经解剖学测量。第三个挑战是评估如何结合这些措施来最好地预测以后的发育结果。我们将与儿童医院和伦敦健康科学中心合作，开发一种临床实践工具，结合解剖、功能和神经行为评估，以提高诊断准确性并促进早期干预