Regulation of uterine adaptation to pregnancy by sphingosine 1-phosphate, a bioactive phopholipid

1-磷酸鞘氨醇（一种生物活性磷脂）调节子宫对妊娠的适应

• 批准号: 356087-2008
• 负责人: Hemmings, Denise
• 金额: $ 1.82万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=504084
• 关键词: Regulation; uterine; adaptation; pregnancy; sphingosine

Pregnancy is accompanied by dramatic uterine adaptations to allow for development of a healthy placenta and to provide a safe environment in which to grow. This changes abruptly at the end of pregnancy when the uterus becomes activated and begins contracting to deliver the baby. Current research on the regulation of all these uterine changes focus primarily on the roles of proteins, hormones and prostaglandins. A well-known phospholipid which has recently been identified as an important factor within the reproductive field is sphingosine 1-phosphate (S1P). However, little is known about the role of S1P in uterine adaptations to pregnancy. The long-term objectives of my program of research are to define the role of S1P in pregnancy-induced events such as 1) implantation and control of trophoblast invasion; 2) uterine activation prior to labour and 3) stimulation of myometrial contractions.

怀孕伴随着戏剧性的子宫适应，以允许健康胎盘的发育，并提供安全的生长环境。这种情况在怀孕结束时突然发生变化，此时子宫被激活并开始收缩以分娩婴儿。目前对所有这些子宫变化的调节的研究主要集中在蛋白质，激素和异黄酮的作用上。最近被鉴定为生殖领域内的重要因子的众所周知的磷脂是1-磷酸鞘氨醇（S1 P）。然而，关于S1 P在子宫适应妊娠中的作用知之甚少。我的研究计划的长期目标是确定S1 P在妊娠诱导事件中的作用，如1）滋养层侵入的植入和控制; 2）分娩前的子宫激活和3）子宫肌层收缩的刺激。