Structural insight into the ERK MAP kinase signalling cascade

ERK MAP 激酶信号级联的结构洞察

• 批准号: 255039
• 负责人: Thevakumaran Neroshan
• 金额: $ 1.27万
• 依托单位: Sinai Health System (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-02-01 至 2013-02-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=255039&lang=en
• 关键词: Biochemistry; Catalytic Switching Mechanism; Enzymology; Pritein Kinase; Signalling; Structural Biology; Substrate Recognition; X-Ray Crystallography

RAF protein kinases are a family of gatekeeping proteins, which tightly guard when growth promoting and cell division pathways are activated in the cell. RAF that has been switched "ON," is instructed to grab hold of, and chemically modify, the protein k

RAF蛋白激酶是一个守门蛋白家族，当细胞中的生长促进和细胞分裂途径被激活时，RAF蛋白激酶严密地保护细胞。 RAF已经被切换为“ON”，被指示抓住并化学修饰蛋白k。