Deciphering the "p53 code": investigating the molecular basis of p53 methylation

破译“p53密码”：研究p53甲基化的分子基础

• 批准号: 255040
• 负责人: Krichevsky Liubov
• 金额: $ 1.27万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-02-01 至 2013-02-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=255040&lang=en
• 关键词: Co-Immunoprecipitation; Enzymatic Assay; Fluorescence Polarization; Lysine; Mass Spectrometry; Methylation; Methyltransferases; P53; Post-Translational Modifications; Reader Proteins

p53 is a protein that mediates a number of critical cellular events including progression through the cell cycle, DNA repair, and cell death. Although seemingly unrelated, all of these functions of p53 prevent tumour formation and progression; thus, p53 i

p53是一种介导许多关键细胞事件的蛋白质，包括细胞周期的进展、DNA修复和细胞死亡。尽管看似无关，但p53的所有这些功能都能阻止肿瘤的形成和发展；因此，p53 I