The multidrug resistance transporter (MDR1) of human malaria: elucidation of its critical function in malaria physiology and its contribution to the development of drug resistance

人类疟疾的多药耐药性转运蛋白（MDR1）：阐明其在疟疾生理学中的关键功能及其对耐药性发展的贡献

• 批准号: 386409-2010
• 负责人: Rohrbach, Petra
• 金额: $ 2.33万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=505954
• 关键词: multidrug; resistance; transporter; MDR1; human

Malaria remains a major infectious disease in many parts of the world, currently accounting for an estimated 5 billion clinical episodes and up to 3 million deaths annually. The human malaria parasite Plasmodium falciparum is a single-celled microorganism that invades human erythrocytes. The parasite has many developmental stages and is perfectly adapted to live in the human vertebrate.

疟疾仍然是世界许多地区的一种主要传染病，目前每年造成约50亿次临床发作和多达300万人死亡。人类疟疾寄生虫恶性疟原虫是一种入侵人类红细胞的单细胞微生物。这种寄生虫有许多发育阶段，非常适合在人类脊椎动物中生活。