Characterization of homo and heterodimeric chemokine CXCR4 and CCR5 receptors association with molecular chaperones and scaffold

同二聚体和异二聚体趋化因子 CXCR4 和 CCR5 受体与分子伴侣和支架关联的表征

• 批准号: 252727
• 负责人: Wertman Jaime
• 金额: $ 1.27万
• 依托单位: Dalhousie University (Nova Scotia)
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-02-01 至 2013-02-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=252727&lang=en
• 关键词: Biomolecular Fluorescence Complementation; Bret/Fret; G Protein-Coupled Receptors; Hiv/Aids; Imaging; Molecular Chaperone; Nherf1; Signalling Specificity; Trafficking Of Receptor Complexes

Human Immunodeficiency Virus (HIV) infection occurs via the attachment of the virus on cell surface receptors, particularly CD4, CXCR4 or CCR5. Yet, while we understand how we can remove the receptors from the cell surface, we do not know very well how th

人类免疫缺陷病毒（HIV）感染是通过病毒附着在细胞表面受体上发生的，特别是CD4、CXCR4或CCR5。然而，虽然我们知道如何将受体从细胞表面移除，但我们并不清楚如何将受体从细胞表面移除