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Identifying substrates of the calpain protease system and elucidating the role of calpain in the cancer cell signalling network

Identifying substrates of the calpain protease system and elucidating the role of calpain in the cancer cell signalling network
识别钙蛋白酶系统的底物并阐明钙蛋白酶在癌细胞信号网络中的作用
批准号：
252878
负责人：
Grieve Stacy
金额：
$9.83万
依托单位：
Queen's University (Kingston, Ontario)
依托单位国家：
加拿大
项目类别：
Fellowship Programs
财政年份：
2012
资助国家：
加拿大
项目状态：
已结题
起止时间：
2012-02-01 至 2015-02-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=252878&lang=en
关键词：
Calpain Mouse Xenograph Models Protease Substrate Proteomics Targeted Therapies

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英文摘要
Improved outcomes for breast cancer patients can be achieved through the development of novel targeted agents which act on key survival and proliferation pathways in cancer cells. This project explores calpain as a novel therapeutic target in breast can
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