Identifying substrates of the calpain protease system and elucidating the role of calpain in the cancer cell signalling network

识别钙蛋白酶系统的底物并阐明钙蛋白酶在癌细胞信号网络中的作用

• 批准号: 252878
• 负责人: Grieve Stacy
• 金额: $ 9.83万
• 依托单位: Queen's University (Kingston, Ontario)
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-02-01 至 2015-02-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=252878&lang=en
• 关键词: Calpain; Mouse Xenograph Models; Protease Substrate; Proteomics; Targeted Therapies

Improved outcomes for breast cancer patients can be achieved through the development of novel targeted agents which act on key survival and proliferation pathways in cancer cells. This project explores calpain as a novel therapeutic target in breast can

通过开发作用于癌细胞中关键存活和增殖途径的新型靶向药物，可以改善乳腺癌患者的预后。 本项目探讨钙蛋白酶作为乳腺癌的一种新的治疗靶点