Obesity and Development of a Diabetes Mellitus-Like State in Pregnancy: Investigating a Role for Regulation of the Human Placental Growth Hormone Genes

妊娠期肥胖和糖尿病样状态的发展：研究人胎盘生长激素基因的调节作用

• 批准号: 259736
• 负责人: Cattini Peter A
• 金额: $ 7.36万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-03-01 至 2014-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=259736&lang=en
• 关键词: Epigenetic Events/Non-Coding Rnas; High Fat Diet-Induced Gestational Diabetes; Human Placenta; Human Placental Hormone Genes; Pregnancy; Transgenic Mice

THE PROBLEM is that 1 in 25 women will develop glucose intolerance, or diabetes mellitus (DM)-like state during pregnancy. This increases the risk to the baby, as well as for obesity and type 2 DM (needing insulin) in later life. WHAT'S GOING ON? There is

问题是25个妇女中就有1个会在怀孕期间出现葡萄糖耐受不良或糖尿病（DM）样状态。这增加了婴儿的风险，以及在以后的生活中肥胖和2型糖尿病（需要胰岛素）的风险。怎么回事？有