Regulation of PTEN

PTEN的监管

• 批准号: 258944
• 负责人: Anderson Deborah H
• 金额: $ 10.21万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-03-01 至 2014-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=258944&lang=en
• 关键词: Breast Cancer; Pi3k/Pten Pathway; Protein Crystallization & Structure Determination; Protein:Protein Interactions; Surface Plasmon Resonance; Tumor Suppressor Protein

The function of the PTEN protein in normal cells is to turn off cellular pathways that cause cell growth and cell survival. So PTEN blocks tumor formation. In many different kinds of human cancers (e.g. breast, prostate and endometrium), the PTEN protein

正常细胞中PTEN蛋白的功能是关闭导致细胞生长和细胞存活的细胞通路。所以PTEN阻止了肿瘤的形成。在许多不同种类的人类癌症（例如乳腺癌、前列腺癌和子宫内膜癌）中，PTEN蛋白质在肿瘤中表达。