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Systematic analysis of the roles of solvent exposed residues in the highly conserved zinc binding region of the human papillomavirus (HPV) type 16 E7 oncoprotein

Systematic analysis of the roles of solvent exposed residues in the highly conserved zinc binding region of the human papillomavirus (HPV) type 16 E7 oncoprotein
系统分析人乳头瘤病毒 (HPV) 16 型 E7 癌蛋白高度保守的锌结合区域中溶剂暴露残基的作用
批准号：
184367
负责人：
Todorovic Biljana
金额：
$7.65万
依托单位：
University of Western Ontario
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2008
资助国家：
加拿大
项目状态：
已结题
起止时间：
2008-10-01 至 2011-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=184367&lang=en
关键词：
Cancer Cell Cycle Regulation E7 Oncoprotein Human Papillomavirus Protein-Protein Interaction

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英文摘要
High-risk types of human papillomaviruses (HPV) are the causative agents of the majority of cervical cancers worldwide and an increasing number of head and neck cancers. HPV infection forces normally quiescent cells to enter the cell cycle and divide. The
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Identification of novel cellular partners of the HPV 16 E7 oncoprotein that are required for oncogenic transformation
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