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Characterization of V-ATPase subunit isoforms as therapeutic targets for diverse diseases including bone loss in inflammatory arthritis

Characterization of V-ATPase subunit isoforms as therapeutic targets for diverse diseases including bone loss in inflammatory arthritis
V-ATP酶亚基亚型作为多种疾病（包括炎症性关节炎中骨质流失）治疗靶点的表征
批准号：
254898
负责人：
Manolson Morris F
金额：
$42.21万
依托单位：
University of Toronto
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2012
资助国家：
加拿大
项目状态：
已结题
起止时间：
2012-03-01 至 2017-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=254898&lang=en
关键词：
Acidification Arthritis Bone Loss Ion Transport Membrane Proteins Osteoclasts Proton Pumps V-Atpases

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英文摘要
Many essential 'housekeeping' functions in the body require acid to be pumped across the membranes of cells and tissues. Acid is pumped into lysosomes, cellular recycling bins that break down old cell components into reusable building blocks, and it is pu
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Elucidating the role of the V-ATPase "a" subunit in targeting and function: a novel therapeutic target for bone-loss pathologies and cancer
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  • 资助金额：
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