Bioorganic chemistry of unusual fatty acid biomodifications

不常见脂肪酸生物修饰的生物有机化学

• 批准号: 2528-2008
• 负责人: Buist, Peter
• 金额: $ 3.28万
• 依托单位: Carleton University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=513092
• 关键词: Bioorganic; chemistry; unusual; fatty; acid

Our laboratory is engaged in the study of an important group of biological catalysts known as fatty acid modifying enzymes. These proteins are widely distributed in all life-forms and modifiy fatty acid components via highly selective chemistry. The primary focus of our research program is to understand the molecular mechanisms which control the functional outcome as well as the exquisite regio- and stereoselectivity of these enzymic processes. We have developed a series of probes for this purpose and these tools are now being used by several groups in Canada, USA and Europe to study related systems. We plan to continue our fundamental studies with special emphasis on those systems for which 3-D structural information is being obtained. In this manner, emerging trends in reactivity can be correlated with accurate active site models.

我们的实验室致力于研究一组重要的生物催化剂，即脂肪酸修饰酶。 这些蛋白质广泛分布在所有生命形式中，并通过高度选择性化学修饰脂肪酸成分。 我们研究计划的主要重点是了解控制功能结果的分子机制以及这些酶过程的精确区域选择性和立体选择性。为此，我们开发了一系列探针，加拿大、美国和欧洲的多个团体现在正在使用这些工具来研究相关系统。我们计划继续我们的基础研究，特别关注那些正在获取 3D 结构信息的系统。通过这种方式，反应性的新趋势可以与准确的活性位点模型相关联。