Molecular mechanisms of invertebrate visual systems

无脊椎动物视觉系统的分子机制

• 批准号: 171213-2009
• 负责人: Mitchell, Jane
• 金额: $ 3.35万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=513899
• 关键词: Molecular; mechanisms; invertebrate; visual; systems

The G protein coupled signal transduction systems are expressed in most cells of the body and in most living organisms. The invertebrate visual system that we study is the fastest G protein-coupled system in all biology. In my laboaratory we are conducting research in the invertebrate North Atlantic squid that has large eyes that are very similar in structure to humans. Over the past fifteen years my laboratory has isolated many of the proteins involved in the visual system of the squid and we have cloned DNAs encoding these proteins. We have uncovered many of the molecular interactions that both activate and inactivate the visual process in squid and these have led us to a better understanding of how these types of signalling systems work.

G蛋白偶联的信号转导系统在身体的大多数细胞和大多数活生物体中表达。我们研究的无脊椎动物视觉系统是所有生物中最快的G蛋白偶联系统。在我的实验室里，我们正在对北大西洋无脊椎鱿鱼进行研究，这种鱿鱼有着与人类非常相似的大眼睛。 在过去的15年里，我的实验室已经分离出许多与乌贼视觉系统有关的蛋白质，我们还克隆了编码这些蛋白质的DNA。我们已经发现了许多激活和抑制鱿鱼视觉过程的分子相互作用，这些使我们更好地了解这些类型的信号系统如何工作。