Delineating the role of prohibitin in insulin signaling

描述抑制素在胰岛素信号传导中的作用

• 批准号: 402050-2011
• 负责人: Mishra, Suresh
• 金额: $ 2.91万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=515534
• 关键词: Delineating; role; prohibitin; insulin; signaling

The body gets energy by making glucose from foods. To use this glucose, the body needs insulin. Insulin is a hormone (chemical messenger in the body) which is produced from the pancreas that helps the body control the level of glucose (sugar) in the blood and ensures that the body's energy needs are met. Insulin's action on the body is mediated by a complex, highly integrated network of proteins. In the presence of insulin, the insulin receptor (a protein on the cell surface that juts out and latches onto insulin) initiate insulin signaling (sequence of biochemical reaction) which is responsible for insulin's actions in the body. However, the underlying mechanisms remain to be understood. Our studies have focused on advancing our understanding of insulin signaling and action. We have found that a protein called prohibitin modulates insulin signaling and interacts with a number of proteins known to be involved in insulin signaling. However, the mechanism involved in the role of prohibitin in insulin signaling is not known. In addition, we have found that prohibitin binds to iron. It is not known whether iron binding function of prohibitin is interlinked with its insulin signaling function. In this study we will dissect the underlying mechanism involved in the role of prohibitin in insulin signaling. In addition we will determine whether iron binding function of prohibitin play a role in this process. This study will advance our understanding of a physiologically essential cell-signaling network of insulin in general and provide insight into the role of prohibitin in particular.

身体通过从食物中制造葡萄糖来获得能量。为了使用这些葡萄糖，身体需要胰岛素。胰岛素是一种激素（体内的化学信使），由胰腺产生，帮助身体控制血液中的葡萄糖（糖）水平，并确保满足身体的能量需求。胰岛素对身体的作用是由一个复杂的，高度整合的蛋白质网络介导的。在胰岛素存在的情况下，胰岛素受体（细胞表面上突出并锁定在胰岛素上的蛋白质）启动胰岛素信号传导（生化反应序列），这负责胰岛素在体内的作用。然而，其基本机制仍有待了解。我们的研究集中在推进我们对胰岛素信号传导和作用的理解。我们发现一种叫做抑制素的蛋白质调节胰岛素信号，并与许多已知参与胰岛素信号的蛋白质相互作用。然而，抑制素在胰岛素信号传导中的作用机制尚不清楚。此外，我们发现抑制素与铁结合。目前尚不清楚是否铁结合功能的抑制素与其胰岛素信号转导功能。在这项研究中，我们将剖析的潜在机制，在胰岛素信号中的作用，抑制素。此外，我们还将确定抑制素的铁结合功能是否在这一过程中发挥作用。这项研究将促进我们对胰岛素生理学必需的细胞信号网络的总体了解，并特别提供对抑制素作用的深入了解。