Role and mechanisms of action of the mammalian target of rapamycin (mTOR) in cartilage development and osteoarthritis in vivo

哺乳动物雷帕霉素靶点（mTOR）在体内软骨发育和骨关节炎中的作用和作用机制

• 批准号: 265767
• 负责人: Kapoor Mohit
• 金额: $ 33.15万
• 依托单位: Centre hospitalier de l'Universit de Montral (CHUM)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-09-01 至 2016-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=265767&lang=en
• 关键词: Autophagy; Cartilage; Chondrocytes; Endochondral Ossification; Mtor; Osteoarthritis

Despite extensive research, the mechanisms by which osteoarthritis (OA) can be prevented or treated still remain to be determined. Cartilage is the most critical tissue in our body which is destroyed during OA. Cartilage consists of only one type of speci

尽管进行了广泛的研究，但骨关节炎（OA）的预防或治疗机制仍有待确定。软骨是我们身体中最重要的组织，在OA期间被破坏。腕足动物仅由一种类型的物种组成，