Local dissociation of DNA/DNA and DNA/RNA from the ribonuclease H active site of HIV-1 reverse transcriptase: Implications for (+)-strand DNA synthesis and drug design

DNA/DNA 和 DNA/RNA 从 HIV-1 逆转录酶的核糖核酸酶 H 活性位点局部解离：对 ( )-链 DNA 合成和药物设计的影响

• 批准号: 184425
• 负责人: Beilhartz Greg L
• 金额: $ 7.65万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-10-01 至 2011-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=184425&lang=en
• 关键词: Drug Development; Drug Resistance; Hiv; Inhibitors; Mechanism; Mutation; Nucleic Acids; Reverse Transcriptase; Rnase H; Virology

The Human Immunodeficiency Virus type-1 (HIV-1) affects approximately 33 million people globally, with around 2.7 million new cases reported annually, according to UNAIDS. The enzyme used by the HIV-1 virus to replicate itself is called reverse transcrip

据联合国艾滋病规划署称，人类免疫缺陷病毒1型（HIV-1）影响全球约3300万人，每年报告约270万新病例。 HIV-1病毒用来复制自身的酶被称为逆转录酶。