Translational Control of Apolipoprotein B mRNA

载脂蛋白 B mRNA 的翻译控制

• 批准号: 41858-2012
• 负责人: Adeli, Khosrow
• 金额: $ 2.91万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=521596
• 关键词: Translational; Control; Apolipoprotein; mRNA

We are proposing to study the biochemistry and cell biology of proteins important in lipid metabolism. Human liver secretes a number of proteins called "apolipoproteins" which are essential for formation of lipid particles called "lipoproteins". Secretion and metabolism of lipoproteins by the human liver is very important in maintaining the plasma levels of fat and cholesterol. We are interested in the basic molecular and cellular mechanisms which regulate the synthesis and secretion of these proteins. Our laboratory has been studying these mechanisms for the past several years and has made a number of important observations on regulation of apolipoprotein B synthesis. We now propose to continue these investigations to further elucidate key translational control mechanisms.

我们建议研究脂质代谢中重要蛋白质的生物化学和细胞生物学。人类肝脏分泌多种称为“载脂蛋白”的蛋白质，这些蛋白质对于形成称为“脂蛋白”的脂质颗粒至关重要。人类肝脏分泌和代谢脂蛋白对维持血浆中脂肪和胆固醇水平非常重要。我们对调节这些蛋白质合成和分泌的基本分子和细胞机制感兴趣。我们实验室在过去几年中一直在研究这些机制，并对载脂蛋白B合成的调节进行了一些重要的观察。我们现在建议继续这些调查，以进一步阐明关键的翻译控制机制。