Multixenobiotic resistance mechanisms: function and relevance of P-glycoprotein (ABCB1) in teleosts

多异生素耐药机制：P-糖蛋白（ABCB1）在硬骨鱼中的功能和相关性

• 批准号: 121390-2009
• 负责人: Kennedy, Christopher
• 金额: $ 3.21万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=522130
• 关键词: Multixenobiotic; resistance; mechanisms; function; relevance

One basic cellular strategy underlying resistance to foreign chemicals is to reduce intracellular concentrations. One of the most intriguing defense strategies developed is the activity of the multixenobiotic resistance mechanism (MXR), analogous to the multidrug resistant (MDR) mechanism found in mammalian cell lines and tumors of human patients resistant to chemotherapeutic drugs. MXR activity is mediated by the expression of a variety of transmembrane transport proteins, the most common among them being the transmembrane P-glycoprotein, a multidrug resistance transporter (ABCB1).

对外来化学物质的抗性的一个基本细胞策略是降低细胞内浓度。开发的最有趣的防御策略之一是多异生素抗性机制（MXR）的活性，类似于在哺乳动物细胞系和对化疗药物具有抗性的人类患者的肿瘤中发现的多药耐药（MDR）机制。MXR活性由多种跨膜转运蛋白的表达介导，其中最常见的是跨膜P-糖蛋白，一种多药耐药转运蛋白（ABCB 1）。