Mechanisms for podocyte injury and diabetic nephropathy

足细胞损伤和糖尿病肾病的机制

• 批准号: 274742
• 负责人: Geraldes Pedro M
• 金额: $ 7.29万
• 依托单位: Universit de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-09-01 至 2013-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=274742&lang=en
• 关键词: Diabetes; Glycemic Memory; Insulin; Insulin Resistance; Nephropathy; Podocytes; Protein Tyrosine Phosphatase; Survival Factors; Vascular Complications

Clinically evident kidney failure eventually develops in patients with type 1 and continues to progress despite receiving intensified glycemic control. The mechanisms underlying this metabolic memory phenomenon on progression of kidney damage are not comp

临床上明显的肾衰竭最终在1型患者中发展，并且尽管接受了强化的血糖控制，但仍继续进展。这种代谢记忆现象在肾损伤进展中的潜在机制并不复杂。