Prediction and design of nucleic acid secondary structure and folding pathways: from theory to tools

核酸二级结构和折叠途径的预测和设计：从理论到工具

• 批准号: 217192-2011
• 负责人: Condon, Anne
• 金额: $ 3.57万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=523719
• 关键词: Prediction; design; nucleic; acid; secondary

My long-term research goals are to provide effective computational methods for predicting function of nucleic acids - DNA and RNA molecules - and for designing nucleic acids with novel functions. Prediction methods are essential to biologists who wish to better understand cellular RNA function, such as the central roles of RNA in gene regulation, and causes of malfunction. Design methods enable scientists to create new molecules with useful functions, e.g., in disease diagnosis and therapy. My research particularly aims to advance the nascent field of molecular (DNA and RNA) programming, which makes possible scalable, general-purpose molecular designs that could transform the ways in which we monitor and mediate molecular dynamics within the cell or other micro-environments.

我的长期研究目标是为预测核酸-DNA和RNA分子-的功能提供有效的计算方法，并设计具有新功能的核酸。对于希望更好地了解细胞RNA功能的生物学家来说，预测方法是必不可少的，例如RNA在基因调控中的核心作用，以及故障的原因。设计方法使科学家能够创造出具有有用功能的新分子，例如在疾病诊断和治疗中。我的研究特别旨在推进分子(DNA和RNA)编程的新领域，这使得可扩展的、通用的分子设计成为可能，这些设计可以改变我们在细胞或其他微环境中监测和调节分子动力学的方式。