Synthesis and Characterization of Nanostructured Biomaterials

纳米结构生物材料的合成和表征

• 批准号: 262754-2013
• 负责人: Burrell, Robert
• 金额: $ 1.6万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=525558
• 关键词: Synthesis; Characterization; Nanostructured; Biomaterials

Silver nanostructured materials are used daily in wound treatment around the world. These new materials, which are made of equiaxed crystals that are less than 20 billonths of a meter in diameter, have dramatically changed the lives of people with chronic wounds like pressure sores and venous ulcers. In the past some of these wounds would not heal despite receiving the best available treatment, but when treated with nanocrystalline silver they healed very well. Remarkably this same nanotechnology may one day benefit people with diverse diseases like eczema, psoriasis asthma and rheumatoid arthritis. This research program will look at nanostructured noble metals, including gold and silver, with a goal of optimizing their structures to achieve various biological responses including control of inflammation. Researchers will use sophisticated vacuum equipment to create various types of nanostructured materials and then use advanced chemical techniques to characterize the final materials. Biological activity assessments will also be made and correlated to the nanostructure of the material so that the structure-activity relationships can be established. This will allow researchers to optimize the materials nanostructure for various applications and make the development of therapeutic products possible.

银纳米结构材料每天都在世界各地的伤口治疗中使用。这些新材料是由直径小于200亿分之一米的等轴晶体制成的，它们极大地改变了患有压疮和静脉溃疡等慢性伤口的人们的生活。在过去，有些伤口即使接受了最好的治疗也无法愈合，但当用纳米晶银治疗时，它们愈合得很好。值得注意的是，同样的纳米技术有一天可能会使患有湿疹、牛皮癣、哮喘和类风湿性关节炎等各种疾病的人受益。这个研究项目将着眼于纳米结构的贵金属，包括金和银，目标是优化它们的结构，以实现包括控制炎症在内的各种生物反应。研究人员将使用先进的真空设备来制造各种类型的纳米结构材料，然后使用先进的化学技术来表征最终材料。生物活性评估也将进行，并与材料的纳米结构相关联，以便建立结构-活性关系。这将使研究人员能够优化各种应用的材料纳米结构，并使治疗产品的开发成为可能。