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Modulating the function of SCF ubiquitin ligases through ubiquitin-based binders

Modulating the function of SCF ubiquitin ligases through ubiquitin-based binders
通过基于泛素的结合剂调节 SCF 泛素连接酶的功能
批准号：
270042
负责人：
Gorelik Maryna
金额：
$9.83万
依托单位：
University of Toronto
依托单位国家：
加拿大
项目类别：
Fellowship Programs
财政年份：
2012
资助国家：
加拿大
项目状态：
已结题
起止时间：
2012-10-01 至 2015-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=270042&lang=en
关键词：
Combinatorial Libraries E3 Ubiquitin Ligase F-Box Protein High Throughput Screening Phage Display Protein Degradation Scf Ubiquitin Ligase Structural Analysis Ubiquitin Proteasome Pathway Ubiquitin-Based Inhibitors/Activators

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The ubiquitin proteasome system is responsible for timely degradation of proteins inside the cell, which is absolutely critical for proper cellular function. Through a series of enzymatic steps, a small protein called ubiquitin is attached to other protei
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