Human complementation of yeast mutations to identify candidate cancer therapeutic targets

人类酵母突变互补以确定候选癌症治疗靶点

• 批准号: 283912
• 负责人: Hamza Akil
• 金额: $ 7.65万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-10-01 至 2015-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=283912&lang=en
• 关键词: Cancer Predisposing Genes; Chromosome Instability (Cin) Genes; Complementation; Saccharomyces Cerevisiae; Synthetic Genetic Analysis; Synthetic Lethality; Tumor-Specific Mutations

DNA instability plays an important role in the initiation and progression of cancer. Sequencing of DNA in cancer patients has identified many tumor-specific mutations that are not found in normal cells. These tumor-specific mutations were predominantly fo

DNA不稳定性在癌症的发生和发展中起着重要作用。癌症患者的DNA测序已经确定了许多在正常细胞中没有发现的肿瘤特异性突变。这些肿瘤特异性突变主要发生在