Conformation specific targeting of misfolded superoxide dismutase 1 as an immunotherapeutic strategy for Amyotrophic Lateral Sclerosis.

错误折叠的超氧化物歧化酶 1 的构象特异性靶向作为肌萎缩侧索硬化症的免疫治疗策略。

• 批准号: 277273
• 负责人: Marciniuk Kristen
• 金额: $ 3.82万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-10-01 至 2015-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=277273&lang=en
• 关键词: Amyotrophic Lateral Sclerosis; Conformation Specific Antibodies; Immunotherapy; Peptide Epitope Optimization; Protein Misfolding; Self-Epitope; Sod1; Vaccine Design

Amyotrophic Lateral Sclerosis (ALS), also referred to as "Lou-Gehrig's Disease", is the most common motor neuron disease. ALS is characterized by a rapidly progressive degeneration of motor neurons, leading to a loss of muscle function, which often resul

肌萎缩侧索硬化症（ALS），也称为“Lou-Gehrig病”，是最常见的运动神经元疾病。 肌萎缩侧索硬化症的特征是运动神经元的快速进行性变性，导致肌肉功能丧失，这通常会导致