Mechanisms underlying respiratory motor plasticity

呼吸运动可塑性的机制

• 批准号: 327078-2012
• 负责人: Peever, John
• 金额: $ 2.26万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=526813
• 关键词: Mechanisms; underlying; respiratory; motor; plasticity

Context: The respiratory control system is not just reflexive - it is smart, it learns and in fact it has a working memory. The respiratory system listens to and carefully remembers how previous stimuli affect breathing. Respiratory memory is laid down by adjusting synaptic strength between respiratory neurons. Repeated respiratory stimuli (e.g. apnea) induce a form of memory that strengthens the ability of respiratory motoneurons to trigger contraction of breathing muscles. This type of respiratory motor plasticity is called long-term facilitation (LTF) and it may serve to deepen breathing and improve effective lung ventilation.

背景：呼吸控制系统不仅仅是反射性的-它很聪明，它会学习，事实上它有工作记忆。呼吸系统倾听并仔细记住先前的刺激如何影响呼吸。呼吸记忆是通过调节呼吸神经元之间的突触强度来形成的。重复的呼吸刺激（例如呼吸暂停）诱导一种形式的记忆，增强呼吸运动神经元触发呼吸肌收缩的能力。这种类型的呼吸运动可塑性被称为长期促进（LTF），它可能有助于加深呼吸和改善有效的肺通气。