Mode of action of membrane-targeting antimicrobial compounds

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Membrane-targeting antimicrobials (MTAs) have been employed successfully in medicine for a number of years. There are theoretical reasons why these antimicrobials might delay or even eliminate resistance development in sensitive pathogens. Yet surprisingly, use of MTAs against plant and food pathogens is still very limited. It is hypothesized that MTAs have a mode of action that is difficult for microorganisms to overcome and could therefore provide efficient and, most importantly, durable methods of control. The lack of fundamental knowledge on the mode of action of MTAs has most definitely hampered the efficient use of these novel antimicrobials.