Mode of action of membrane-targeting antimicrobial compounds

膜靶向抗菌化合物的作用模式

• 批准号: 341690-2010
• 负责人: Avis, Tyler
• 金额: $ 1.97万
• 依托单位: Carleton University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=527425
• 关键词: Mode; action; membrane; targeting; antimicrobial

Membrane-targeting antimicrobials (MTAs) have been employed successfully in medicine for a number of years. There are theoretical reasons why these antimicrobials might delay or even eliminate resistance development in sensitive pathogens. Yet surprisingly, use of MTAs against plant and food pathogens is still very limited. It is hypothesized that MTAs have a mode of action that is difficult for microorganisms to overcome and could therefore provide efficient and, most importantly, durable methods of control. The lack of fundamental knowledge on the mode of action of MTAs has most definitely hampered the efficient use of these novel antimicrobials.

膜靶向抗菌剂（MTA）已成功地应用于医学多年。这些抗菌剂可能延迟甚至消除敏感病原体的耐药性发展，这是有理论依据的。然而令人惊讶的是，针对植物和食品病原体的MTA的使用仍然非常有限。据推测，MTA具有微生物难以克服的作用模式，因此可以提供有效且最重要的是持久的控制方法。缺乏对MTA作用模式的基本知识，最明显地阻碍了这些新型抗菌剂的有效使用。