Structure and Function of E. coli Tyrosine Kinase: a Regulator of Capsule Development and Antibiotic Resistance in Gram-Negative Bacterial Pathogens

大肠杆菌酪氨酸激酶的结构和功能：革兰氏阴性细菌病原体荚膜发育和抗生素耐药性的调节剂

• 批准号: 283923
• 负责人: Chesterman Chelsy C
• 金额: $ 5.1万
• 依托单位: Queen's University (Kingston, Ontario)
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-10-01 至 2014-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=283923&lang=en
• 关键词: Antibiotic Resistance; Bacterial Pathogens; Computational Modelling; In Vivo Functional Assays; Membrane Proteins; Pharmaceutical Design; Prokaryotic Tyrosine Kinases; Protein Interactions; Protein Structure And Function; X-Ray Crystallography

Most E. coli strains are not harmful, but some have acquired genes that make them a serious health concern. These virulence genes encode different traits, such as the ability to produce toxins, protect pathogens from the immune system, or provide antibiot

大多数E.大肠杆菌菌株是无害的，但有些已经获得的基因，使他们成为一个严重的健康问题。这些毒力基因编码不同的特性，如产生毒素、保护病原体免受免疫系统侵害或提供抗生素的能力。