Novel tools for controlling singlet oxygen in cellular systems.

用于控制细胞系统中单线态氧的新工具。

• 批准号: 355548-2012
• 负责人: Heyne, Belinda
• 金额: $ 2.55万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=527808
• 关键词: Novel; tools; controlling; singlet; oxygen

Images are the primary means by which people perceive the universe. Current technology has transformed this perception, as is particularly evident in the biological sciences, as live cell imaging delves into the mysteries of subcellular architecture and function. Imaging techniques are revolutionizing biology by permitting the observation of events in real-time, as they occur inside of living organisms. Unfortunately, the imaging of living organisms almost guarantees the formation of singlet oxygen, a highly reactive and toxic form of molecular oxygen, which is dangerous to the living organism being observed and which deteriorates the data obtained from the specimen.

图像是人们感知宇宙的主要手段。目前的技术已经改变了这种看法，这在生物科学中尤其明显，因为活细胞成像深入研究了亚细胞结构和功能的奥秘。 成像技术通过允许实时观察生物体内部发生的事件来彻底改变生物学。 不幸的是，活生物体的成像几乎保证了单线态氧的形成，单线态氧是分子氧的高度反应性和毒性形式，其对被观察的活生物体是危险的，并且其使从样本获得的数据劣化。