Mechanism of nutritional regulation of protein metabolism in skeletal muscle

骨骼肌蛋白质代谢的营养调节机制

• 批准号: 355984-2009
• 负责人: Adegoke, Olasunkanmi
• 金额: $ 1.82万
• 依托单位: York University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=527981
• 关键词: Mechanism; nutritional; regulation; protein; metabolism

Skeletal muscle is an important tissue in all animals, because of its significant roles in substrate utilization and body homeostasis. Proteins are critical components of muscle (about 65% of muscle weight is protein). Therefore to control muscle growth one has to control protein metabolism in this tissue. However, we do not know the mechanisms by which food regulates protein metabolism in muscle. An understanding of these mechanisms will help to better appreciate how metabolism and growth of an animal are regulated. My research will shed more light on this. An important player in protein synthesis in muscle is a protein called S6K1. Using nutritional manipulation, muscle and cell incubation, I seek to identify how S6K1 regulates protein synthesis when amino acids, an important class of nutrients in muscle, are supplied. I will also examine how this regulation is modified in insulin resistant states. The fundamental understanding gained in this research will help to better understand how nutrients regulate metabolism and growth. Our results may also help future studies examining questions relating to nutrition and human conditions such as obesity and metabolic syndrome .

骨骼肌是所有动物的重要组织，因为它在底物利用和身体稳态中发挥着重要作用。蛋白质是肌肉的重要组成部分（约 65% 的肌肉重量是蛋白质）。因此，为了控制肌肉生长，必须控制该组织中的蛋白质代谢。然而，我们不知道食物调节肌肉蛋白质代谢的机制。了解这些机制将有助于更好地理解动物的新陈代谢和生长是如何调节的。我的研究将进一步阐明这一点。肌肉蛋白质合成中的一个重要角色是一种名为 S6K1 的蛋白质。通过营养操作、肌肉和细胞孵化，我试图确定当氨基酸（肌肉中的一类重要营养素）被供应时，S6K1 如何调节蛋白质合成。我还将研究在胰岛素抵抗状态下如何修改这一调节。这项研究中获得的基本了解将有助于更好地了解营养物质如何调节新陈代谢和生长。我们的结果还可能有助于未来研究与营养和人类状况（例如肥胖和代谢综合征）相关的问题。