Mechanism of nutritional regulation of protein metabolism in skeletal muscle

骨骼肌是所有动物的重要组织，因为它在底物利用和体内平衡中起着重要作用。蛋白质是肌肉的重要组成部分（肌肉重量的65%是蛋白质）。因此，要控制肌肉生长，就必须控制肌肉组织中的蛋白质代谢。然而，我们不知道食物调节肌肉中蛋白质代谢的机制。对这些机制的理解将有助于更好地理解动物的新陈代谢和生长是如何被调节的。我的研究将进一步阐明这一点。肌肉中蛋白质合成的重要参与者是一种叫做S6K1的蛋白质。通过营养操纵、肌肉和细胞孵育，我试图确定当氨基酸（肌肉中重要的一类营养物质）供应时，S6K1是如何调节蛋白质合成的。我还将研究这种调节在胰岛素抵抗状态下是如何改变的。在这项研究中获得的基本认识将有助于更好地理解营养物质如何调节新陈代谢和生长。我们的研究结果也可能有助于未来研究与营养和人类状况有关的问题，如肥胖和代谢综合征。

Skeletal muscle is an important tissue in all animals, because of its significant roles in substrate utilization and body homeostasis. Proteins are critical components of muscle (about 65% of muscle weight is protein). Therefore to control muscle growth one has to control protein metabolism in this tissue. However, we do not know the mechanisms by which food regulates protein metabolism in muscle. An understanding of these mechanisms will help to better appreciate how metabolism and growth of an animal are regulated. My research will shed more light on this. An important player in protein synthesis in muscle is a protein called S6K1. Using nutritional manipulation, muscle and cell incubation, I seek to identify how S6K1 regulates protein synthesis when amino acids, an important class of nutrients in muscle, are supplied. I will also examine how this regulation is modified in insulin resistant states. The fundamental understanding gained in this research will help to better understand how nutrients regulate metabolism and growth. Our results may also help future studies examining questions relating to nutrition and human conditions such as obesity and metabolic syndrome .