Impact on the biology of mucosal tolerance in exposure to haptenated antigens

半抗原暴露对粘膜耐受性生物学的影响

• 批准号: 371268-2009
• 负责人: Yang, PingChang
• 金额: $ 1.82万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=528171
• 关键词: Impact; biology; mucosal; tolerance; exposure

This research program is designed to investigate the cellular and molecular mechanisms by which haptenated antigens interfere with the biological aspects of mucosal tolerance. Both tolerogenic dendritic cells and regulatory T cells play a critical role in the establishment/maintenance of mucosal tolerance; the latter plays a central role in maintaining the homeostasis in the body. Defect of either regulatory T cells or tolerogenic dendritic cells plays a critical role in skewed cellular responses.

该研究计划旨在研究半抗原抗原干扰粘膜耐受性生物学方面的细胞和分子机制。致耐受性树突状细胞和调节性T细胞在粘膜耐受的建立/维持中起关键作用;后者在维持体内稳态中起核心作用。调节性T细胞或致耐受性树突状细胞的缺陷在偏斜的细胞反应中起关键作用。