Molecular signals of multicellularity

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In a given organism (be it human or any other developed organism) there are millions and millions of cells, but we know very little about how these cells communicate with each other. These communication networks are critical important to the normal function of an organism. At present, we know in many cases cell-to-cell interactions are mediated by small chemical molecules that act as messengers. Finding these messengers is very difficult, and without them we can not fully appreciate how the individual cells can coordinate their functions to become a multicellular organism.