Exploiting bacterial growth laws to characterize indirect mechanisms for generating phenotypic heterogeneity from isogenic populations

利用细菌生长规律来表征从同基因群体产生表型异质性的间接机制

• 批准号: 372011-2011
• 负责人: Scott, Matthew
• 金额: $ 2.49万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=528460
• 关键词: Exploiting; bacterial; growth; laws; characterize

From the time of Jacob and Monod, a dominant theme running through microbiology and bacterial physiology is the idea that the information encoded in DNA can be connected to the physiological state of the organism through a multi-scale assembly of simple elements: the gene within an operon, the operon within a network and the network within the cell. This bottom-up approach to the understanding (and, more recently, the synthesis) of genetic networks is analogous to the engineering principles of electrical circuit design - a fruitful analogy that has lead to significant conceptual advances particularly in the burgeoning field of systems biology. But the limitation of this analogy is, of course, that electrical circuits do not grow and divide.

从Jacob和Monod的时代开始，贯穿微生物学和细菌生理学的一个主要主题是，DNA编码的信息可以通过简单元素的多尺度组装与生物体的生理状态联系起来：操纵子中的基因，网络中的操纵子和细胞中的网络。这种自下而上的理解（以及最近的合成）遗传网络的方法类似于电路设计的工程原理——一个富有成效的类比，导致了重大的概念进步，特别是在新兴的系统生物学领域。当然，这种类比的局限性在于电路不能生长和分裂。