Clinically Relevant Artificial Lubricants for Implant Wear Testing
用于种植体磨损测试的临床相关人工润滑剂
基本信息
- 批准号:402036-2012
- 负责人:
- 金额:$ 1.82万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2013
- 资助国家:加拿大
- 起止时间:2013-01-01 至 2014-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Total joint arthroplasty (TJA) is a well established surgical intervention used to provide pain relief and improve the quality of life for patients suffering from arthritis. With increasing life expectancy and a growing trend that points to younger and more active patients undergoing TJA, it is even more imperative to maximize the longevity of these medical devices. TJAs can fail due to wear-particle induced bone resorption that can cause expensive and time-intensive revision surgery; a surgery that is also associated with a higher risk of patient morbidity. Wear evaluation of total joint replacements prior to large scale implantation has become a standardized procedure to identify bearing material wear characteristics, and to estimate their possible in vivo wear performance; however, current standardized test conditions have shown that the lubricants` biochemical and microbiological characteristics do not match the in vivo conditions. The main objective of this present proposal is to develop and validate a more clinically relevant lubricant for implant (hip and knee) wear testing that is supported by both clinical findings and by in vitro wear tests. In order to achieve this objective, a multi-disciplinary approach is required. This approach involves a combination of mechanical engineering, orthopaedic, biochemical, and microbiological research to develop a more clinically relevant lubricant that permits the sterile evaluation of implants in vitro. The proposed studies include the analysis of synovial fluid from patients, followed by in vitro simulator wear testing, wear particle assessment, wear surface analysis, and computational modeling of the wear process, all of which are an integral part of interdisciplinary research and medical device product development. Using the developed knowledge of implant lubrication, the proposed research will extend in the long term to the modeling of the lubrication phenomena that occur in both joint simulator testing and in vivo. These endeavors will generate scientific evidence to encourage national and international regulatory bodies to gradually integrate the new scientific knowledge into standardized test procedures, which may facilitate the development of more durable implants.
全关节置换术(TJA)是一种成熟的手术干预,用于缓解疼痛和改善关节炎患者的生活质量。随着预期寿命的增加以及越来越多的年轻和更活跃的患者接受TJA的趋势,最大限度地延长这些医疗设备的寿命变得更加迫切。由于磨损颗粒诱导的骨吸收,TJAs可能失效,这可能导致昂贵且耗时的修复手术;这种手术也与较高的患者发病风险相关。在大规模植入之前对全关节置换术进行磨损评估已经成为一种标准化的程序,用于识别轴承材料的磨损特性,并估计其可能的体内磨损性能;然而,目前的标准化测试条件表明,润滑油的生化和微生物特性与体内条件不匹配。本提案的主要目的是开发和验证一种更具临床相关性的用于植入物(髋关节和膝关节)磨损测试的润滑剂,该润滑剂得到临床结果和体外磨损测试的支持。为了实现这一目标,需要一种多学科的方法。该方法涉及机械工程、骨科、生物化学和微生物学研究的结合,以开发一种更临床相关的润滑剂,允许体外植入物的无菌评估。拟议的研究包括分析患者的滑液,随后进行体外模拟器磨损测试,磨损颗粒评估,磨损表面分析和磨损过程的计算建模,所有这些都是跨学科研究和医疗器械产品开发的组成部分。利用已开发的种植体润滑知识,拟议的研究将长期扩展到关节模拟器测试和体内发生的润滑现象的建模。这些努力将产生科学证据,鼓励国家和国际监管机构逐步将新的科学知识纳入标准化的测试程序,这可能有助于开发更耐用的植入物。
项目成果
期刊论文数量(0)
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Brandt, JanMels其他文献
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{{ truncateString('Brandt, JanMels', 18)}}的其他基金
Clinically Relevant Artificial Lubricants for Implant Wear Testing
用于种植体磨损测试的临床相关人工润滑剂
- 批准号:
402036-2012 - 财政年份:2014
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Clinically Relevant Artificial Lubricants for Implant Wear Testing
用于种植体磨损测试的临床相关人工润滑剂
- 批准号:
402036-2012 - 财政年份:2012
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
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