Derivation of sinoatrial node pacemaker cells from human pluripotent stem cells for the generation of bio-artificial pacemakers.

从人类多能干细胞中衍生出窦房结起搏器细胞，用于生成生物人工起搏器。

• 批准号: 275631
• 负责人: Protze Stephanie I
• 金额: $ 10.2万
• 依托单位: University Health Network (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-11-01 至 2014-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=275631&lang=en
• 关键词: Bio-Artificial Pacemaker; Cardiomyocyte Subtype Specification; Cardiomyocyte Surface Marker; Cardiomyocytes; Heart Development; Human Embryonic Stem Cells; Regenerative Therapy; Signaling Pathways; Sinoatrial Node Pacemaker Cells; Stem Cell Differentiatio

It is now possible to routinely generate cardiomyocytes from human embryonic stem cells (hESCs). The heart is composed of two major cardiomyocyte subtypes: the working myocardium consisting of atrial and ventricular myocytes and the pacemaker myocardium c

现在可以常规地从人胚胎干细胞（hESC）产生心肌细胞。心脏由两种主要的心肌细胞亚型组成：由心房和心室肌细胞组成的工作心肌和起搏心肌。