"Cadmium, cell signaling and the cytoskeleton"

“镉、细胞信号传导和细胞骨架”

• 批准号: 418208-2012
• 负责人: Templeton, Douglas
• 金额: $ 1.89万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=531045
• 关键词: Cadmium; cell; signaling; cytoskeleton

Cadmium is a metallic element that has been accumulating in our environment since the beginning of the industrial age. It has no essential biological function and is highly toxic. One of its major targets is the kidney, and we have found that a type of kidney cell called the mesangial cell has unique responses to this metal. Cadmium affects the way signals operate in this cell, and affects the arrangement of the internal skeleton of the cell. It causes oxygen to be activated, and leads to cell death by several different pathways. Our research is directed towards understanding how cadmium exerts its toxic effects on cells. We are also using this system to learn more about fundamental interactions among signaling, cell structure, and cell death.

镉是一种金属元素，自工业时代开始以来一直在我们的环境中积累。 它没有基本的生物学功能，而且毒性很强。 它的主要靶点之一是肾脏，我们发现一种叫做系膜细胞的肾细胞对这种金属有独特的反应。 镉会影响细胞中信号的运作方式，并影响细胞内部骨架的排列。 它导致氧气被激活，并通过几种不同的途径导致细胞死亡。 我们的研究旨在了解镉如何对细胞产生毒性作用。 我们还使用这个系统来了解更多关于信号传导，细胞结构和细胞死亡之间的基本相互作用。