Cellular and Molecular Physiology of Sympathetic Innervation of Vascular Smooth Muscle

血管平滑肌交感神经支配的细胞和分子生理学

• 批准号: 418642-2012
• 负责人: Poburko, Damon
• 金额: $ 2.26万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=531286
• 关键词: Cellular; Molecular; Physiology; Sympathetic; Innervation

My lab will the regulation of vascular smooth muscle (VSM) tone that controls blood vessel diameter and therefore blood pressure and blood supply. VSM tone is a balance of contractile and relaxing signals from nerves in the blood vessels. We focus on the contractile signals from sympathetic nerves that affect our daily lives. Over-active sympathetic nerves are associated with obesity and hypertension, while under-active sympathetic nerves can cause us to see stars when we stand-up. This proposal aims to systematically and decisively determine three basic aspects of sympathetic regulation of VSM.

我的实验室将研究血管平滑肌（VSM）张力的调节，它控制血管直径，从而控制血压和血液供应。VSM张力是来自血管中神经的收缩和舒张信号的平衡。我们关注的是影响我们日常生活的交感神经的收缩信号。过度活跃的交感神经与肥胖和高血压有关，而不活跃的交感神经会使我们在站立时看到星星。该建议旨在系统地、果断地确定VSM交感神经调节的三个基本方面。