Identification of the cell surface receptor for the aleutian disease parvovirus

阿留申病细小病毒细胞表面受体的鉴定

• 批准号: 421306-2011
• 负责人: Benkel, Bernhard
• 金额: $ 1.86万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=531710
• 关键词: Identification; cell; surface; receptor; aleutian

Mink ranching is a multi-million dollar industry in Canada with the bulk of the pelts exported to buyers worldwide. Canadian mink pelts are prized internationally for their premium quality. The mink industry, in general, is concentrated in areas where other agricultural activities are impeded by soil and/or climatic constraints. This is particularly true of Nova Scotia, which produces approximately one half of Canada's mink pelts, and where the industry's use of fish and other animal by-products helps the local economy without putting pressure on the available resources. The primary disease threat to the mink industry in Canada and worldwide, at this time, is the Aleutian disease virus which continues to impact mink ranching despite an extensive, costly monitoring program. The objective of this study is the identification of the receptor protein that the Aleutian disease virus uses to enter susceptible cells in the mink. Identification of the viral receptor protein is intended to provide new fundamental information to serve as the basis for a long term solution to the Aleutian disease problem.

水貂牧场在加拿大是一个价值数百万美元的行业，大部分毛皮出口到世界各地的买家。加拿大水貂毛皮以其优质的品质在国际上享有盛誉。一般来说，水貂产业集中在其他农业活动因土壤和/或气候限制而受阻的地区。新斯科舍省的情况尤其如此，加拿大大约一半的貂皮都是由新斯科舍省生产的，该行业使用鱼类和其他动物副产品有助于当地经济，而不会对现有资源构成压力。目前，加拿大乃至全世界水貂养殖业面临的主要疾病威胁是阿留申病病毒，尽管实施了广泛而昂贵的监测计划，但该病毒仍在继续影响水貂养殖场。本研究的目的是鉴定阿留申病病毒进入水貂敏感细胞的受体蛋白。识别病毒受体蛋白的目的是提供新的基本信息，作为长期解决阿留申病问题的基础。