Role of N-myristoyltransferase in Cellular Differentiation and Function.

蛋白质是细胞中基因的功能性输出。一般来说，蛋白质调节细胞的生理功能。根据细胞的生理需要，蛋白质的结构会发生变化，使其活跃或不活跃。蛋白质结构的改变被称为蛋白质修饰，各种分子附着在蛋白质上对其进行修饰。在蛋白质中加入脂肪（脂肪酸）分子就是这样一种蛋白质修饰，它改变了蛋白质在细胞中的定位和激活。这些油腻蛋白在细胞功能中起着重要作用。脂肪酸加入蛋白质是由酰基转移酶催化的。拟议的研究项目旨在了解一种特殊的酰基转移酶n -肉豆蔻酯转移酶（NMT）的作用，该酶将脂肪分子（肉豆蔻酸，14碳脂肪酸）附着在调节细胞分化和功能的重要信号蛋白上。

Proteins are functional output of genes in a cell. In general, proteins regulate physiological functions of a cell. Depending on the physiological need of the cell, structure of proteins alters to render them active or inactive. Change in protein structure is called protein modification and various molecules attach to proteins to modify them. Addition of a fat (fatty acid) molecule to protein is one such protein modification that alters its localization and activation in a cell. These greasy proteins play important role in cellular function. Fatty acid addition to protein is catalyzed by acyltransferases. Proposed research project aims at understanding the role of one specific kind of acyltransferase called N-myristolatransferase (NMT) that attaches fat molecule (myristic acid, 14 carbon fatty acid) to important signaling proteins that regulate cellular differentiation and function.