Large-scale identification of suppressors of human disease genes in yeast

酵母中人类疾病基因抑制因子的大规模鉴定

• 批准号: 281948
• 负责人: van Leeuwen Jolanda
• 金额: $ 9.83万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-02-01 至 2016-02-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=281948&lang=en
• 关键词: Genetic Diseases; Genetic Suppression; Next-Generation Sequencing; Synthetic Genetic Array Mapping; Yeast Genetics

Mistakes ("mutations") in DNA can cause damage to cells. Often additional DNA mutations can compensate for the harm caused by the first mutation. This process is referred to as genetic suppression. If the initial mutation occurred in a gene involved in hu

DNA 中的错误（“突变”）可能会对细胞造成损害。通常额外的 DNA 突变可以补偿第一个突变造成的伤害。这个过程被称为基因抑制。如果初始突变发生在与 hu 有关的基因中