Systematic identification of dynamic epigenetic modifications in DNA damage repair for novel cancer therapy

系统鉴定新型癌症疗法 DNA 损伤修复中的动态表观遗传修饰

• 批准号: 284732
• 负责人: Li Shun-Cheng S
• 金额: $ 16.39万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-03-01 至 2016-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=284732&lang=en
• 关键词: Cancer; Chromatin Binding Module; Dna Damage Response; Dynamics; Epigenetics; Mass Spectrometry; Multiple Reaction Monitoring; Peptide Array; Protein Methylation; Proteomics

Epigenetics refers mainly to the study of DNA and histone modifications and their role in regulating the gene transcriptional program in cells. Aberrant epigenetic changes have been associated with a plethora of human diseases, including cancer. Histones

表观遗传学主要是指研究DNA和组蛋白修饰及其在调节细胞内基因转录程序中的作用。异常的表观遗传变化与多种人类疾病有关，包括癌症。组蛋白