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Hepatic Bile Acid and Organic Anion Transporting Polypeptide (OATP) drug uptake transporters as determinants of drug disposition

Hepatic Bile Acid and Organic Anion Transporting Polypeptide (OATP) drug uptake transporters as determinants of drug disposition
肝胆汁酸和有机阴离子转运多肽（OATP）药物摄取转运蛋白作为药物处置的决定因素
批准号：
280071
负责人：
Kim Richard B
金额：
$53.73万
依托单位：
University of Western Ontario
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2013
资助国家：
加拿大
项目状态：
已结题
起止时间：
2013-03-01 至 2018-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=280071&lang=en
关键词：
Clinical Pharmacology Drug Disposition Drug Transporters Liver Transporters Pharmacogenetics

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Liver is widely known as an organ capable of breaking down (metabolism) foreign chemicals and drugs that we ingest, and then secrete such breakdown products into bile for subsequent elimination out of the body. Specifically, we now know that the cells tha
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Organic Anion Transporting Polypeptide (OATP), P-glycoprotein (P-gp), and Breast Cancer Resistance Protein (BCRP) transporters modulate tamoxifen response during breast cancer therapy
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  • 项目类别：
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  • 资助金额：
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  • 批准号：
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