The impact of APOBEC-induced mutations of viral genomes on adaptive immunity in HIV+ individuals

APOBEC 诱导的病毒基因组突变对 HIV 个体适应性免疫的影响

• 批准号: 286281
• 负责人: Larijani Mani
• 金额: $ 25.65万
• 依托单位: Memorial University of Newfoundland
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-03-01 至 2016-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=286281&lang=en
• 关键词: Aids; Hiv; Immune Response; Mutations; Viral Evolution

APOBEC3 enzymes are expressed in cells that are targets of HIV infection. These enzymes attack the DNA copy of HIV after it infects the cell. Consequently, they restrict the replication of HIV in experimental systems that measure infection of cultured c

APOBEC3酶在HIV感染的靶细胞中表达。 这些酶在HIV感染细胞后攻击HIV的DNA拷贝。 因此，它们限制了HIV在实验系统中的复制，这些实验系统测量培养的C